A RAPID DETERMINATION OF CHLORHEXIDINE DIGLUCONATE CONTENT IN ANTIMICROBIAL PREPARATION BY FIRST DERIVATIVE SPECTROPHOTOMETRY
DOI:
https://doi.org/10.22452/mjs.vol30no3.1Abstract
A simple, direct and rapid spectrophotometric method has been developed to determine the chlorhexidine digluconate content in the antimicrobial formulation. The application of first derivative spectrophotometry has managed to eliminate the interferences from other ingredients used in the complex matrices. Measurement is made at = 276.1 nm in which Beer’s law is adhered in the range of 0 – 50 µg/ml. ABSTRAK Teknik analisis yang ringkas, cepat and secara langsung telah dipraktik untuk menentukan kandungan chlorhexidine digluconate dalam formulasi antimicrobial. Penggunaan spectroskopi derivatif pertama telah mampu menyingkirkan gangguan daripada ramuan lain yang digunakan dalam penyediaan formulasi antimicrobial. Analisis telah dibuat pada = 276.1 nm dimana hukum Beer’s telah dipatuhi dalam julat 0 – 50 µg/ml. (Keywords : First derivative spectrophotometry, chlorhexidine digluconate)
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