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This study aims to examine the US’s Myanmar policy from the perspective of pragmatic liberalism and explore the primary factors behind the policy shift in 2009. It fills a gap in the literature by offering a rare analysis of US-Myanmar policy through the lens of pragmatic liberalism. The research methodology employs document search and elite interviews to gather comprehensive insights. The research questions focus on understanding how pragmatic liberalism manifested in Obama’s Myanmar policy and identifying the objectives he aimed to achieve. The findings reveal that Obama’s Myanmar policy aligns with the principles of pragmatic liberalism. It can be analysed through two dimensions: modelling creation and hegemony maintenance. Within the context of Sino-US competition, the primary factor driving the US's policy change in Myanmar is China. Consequently, the US’s policy shift aims to establish a new strategic partner to contain Chinese influence in Southeast Asia, thereby maintaining US hegemony in the region. This study contributes to the understanding of US-Myanmar relations and sheds light on the underlying motivations and dynamics of the US’s policy shift. By adopting a pragmatic liberalist approach, the US seeks to shape Myanmar’s trajectory while safeguarding its strategic interests in the region.